4-Fluorococaine Powder: A Research Reference Overview

4-Fluorococaine (4′-Fluorococaine) is a synthetic tropane derivative and fluorinated analog of cocaine that has been utilized primarily as an analytical reference standard and PET radioligand in neurochemical research. At Foreverchems, we provide 4-Fluorococaine powder exclusively as a qualified reference material for laboratory research and forensic analytical applications.

Chemical Profile

4-Fluorococaine is distinguished from cocaine by the substitution of a fluorine atom at the 4-position of the benzoyl group . Its CAS number is 134507-62-3, with a molecular formula of C₁₇H₂₀FNO₄ and a molecular weight of 321.34 g/mol . The compound retains the tropane skeleton and critical stereochemistry (1R,2R,3S,5S) essential for transporter interactions .

Pharmacologically, 4-Fluorococaine exhibits a distinctive profile compared to its parent compound. While maintaining equipotent inhibition at the dopamine transporter (DAT), it demonstrates approximately 100-fold enhanced affinity for the serotonin transporter (SERT) relative to cocaine . Research published in the Journal of Neurochemistry (1994) confirmed that para-fluorine substitution does not alter cocaine’s interaction with dopamine binding sites but significantly increases potency at serotonin reuptake sites . This selectivity shift has made it valuable as a tool compound for studying serotonergic mechanisms with reduced dopaminergic interference .

Research Context

4-Fluorococaine has been employed as a positron-emitting radioligand ([18F]4′-fluorococaine) in PET studies investigating cocaine binding sites and metabolite contributions to brain imaging . The fluorine-18 label offers a half-life compatible with PET radiotracer applications.

In analytical chemistry, 4-Fluorococaine serves as an internal standard for cocaine analysis in biological fluids. Certified reference materials of 4-Fluorococaine hydrochloride have been documented with purity levels of 98.9 ± 1.9% (mass fraction) by the Australian National Measurement Institute, with GC-FID analysis indicating main component purity exceeding 99% .

Quality Standards at Foreverchems

Every batch of 4-Fluorococaine powder undergoes comprehensive analytical verification. Our products are accompanied by certificates of analysis documenting purity levels, chemical identity, and relevant spectroscopic data. We maintain complete batch records for all reference materials, with HPLC and mass spectrometry data available for each lot.

Documentation and Compliance

Foreverchems provides certificates of analysis and technical documentation to support analytical and forensic research requirements. Our quality assurance framework includes standardized testing protocols and multi-stage verification processes.

Important Notice

The legal status of 4-Fluorococaine varies by jurisdiction. In Canada, it is classified as a controlled substance under Schedule I to the Controlled Drugs and Substances Act as a derivative of ecgonine . In the United States, it is not specifically listed but may be considered controlled under the federal analog provisions . Researchers must verify their legal authority to handle such materials and comply with all applicable regulations in their location. Our products are supplied strictly for laboratory research and analytical reference purposes and are not intended for human consumption.