MDPiHP Crystal: A Research Reference Overview

4-methyl-2-pentanone|3,4-Methylenedioxy-α-pyrrolidinoisohexanophenone (MDPiHP) is a synthetic cathinone belonging to the pyrrolidinophenone class and is a positional isomer of MDPHP. Despite its increasing detection in forensic casework across Europe, MDPiHP remains one of the least characterized new psychoactive substances in the current literature . At Foreverchems, we provide MDPiHP crystal exclusively as a qualified reference material for forensic analytical applications and laboratory research.

Chemical Profile

MDPiHP is distinguished from MDPHP by the position of the methyl group on the alkyl side chain. While MDPHP features a linear hexanophenone chain, MDPiHP possesses a branched isopentanone structure . Its molecular formula is C₁₇H₂₃NO₃ with a molecular weight of 289.37 g/mol . The compound was first reported to the European Union Drugs Agency by Sweden in 2020 .

Pharmacological data on MDPiHP remain extremely limited. One in vitro study cited by Swedish authorities demonstrated that MDPiHP fully inhibits dopamine, norepinephrine, and serotonin transporters, with IC₅₀ values of 1.03 nM at DAT, 27 nM at NET, and 776 nM at SERT, yielding a DAT/SERT ratio of 750—a profile associated with high psychostimulant and abuse potential . However, a 2026 study published in Archives of Toxicology noted that little is known regarding the in vitro, in silico, or in vivo neuropharmacology of MDPiHP and its analogues .

Research Context and Forensic Findings

MDPiHP has been detected in seizures across Sweden, Slovenia, Italy, Germany, Finland, and Austria between 2020 and 2025 . A case series published in Forensic Science International (2026) described the identification of MDPiHP alone in femoral blood, suggesting that it poses toxicological risks independent of its structural isomer MDPHP . The study emphasized the increasing need to chromatographically separate isomers to avoid misclassifying causality in NPS-related intoxication and fatalities.

Metabolic research published in Analytical and Bioanalytical Chemistry (2026) provided the first comprehensive investigation of MDPiHP metabolism, identifying 22 metabolites in human biological samples. Dihydro-MDPiHP and M3 were proposed as biomarkers of intake alongside the parent compound . In China, MDPiHP was added to the controlled substances list effective July 1, 2026, following its emergence as a substance of abuse marketed under names including “yellow powder” and “fake ice” .

Quality Standards at Foreverchems

Every batch of MDPiHP crystal undergoes comprehensive analytical verification. Our products are accompanied by certificates of analysis documenting purity levels, chemical identity, and relevant spectroscopic data. We maintain complete batch records for all reference materials, with HPLC and mass spectrometry data available for each lot.

Documentation and Compliance

Foreverchems provides certificates of analysis and technical documentation to support analytical and forensic research requirements. Our quality assurance framework includes standardized testing protocols and multi-stage verification processes.

Important Notice

MDPiHP is controlled in multiple jurisdictions, including Italy, Lithuania, Norway, and China (effective July 1, 2026) . Researchers must verify their legal authority to handle such materials and comply with all applicable regulations in their location. Our products are supplied strictly for laboratory research and analytical reference purposes and are not intended for human consumption.