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introduction to MDPiHP Crystals.

MDPiHP (3,4-methylenedioxy-α-pyrrolidinoisohexanophenone) is a synthetic cathinone belonging to the pyrovalerone class of compounds. It is the methylenedioxy-substituted analogue of α-PiHP and is structurally related to α-PHP and MDPHP .

First reported to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in August 2020, MDPiHP has been identified in seizures across Europe and represents one of the newer generation pyrovalerone derivatives emerging on the research chemical market . The compound has been detected in forensic casework in countries including Sweden, Italy, Lithuania, and Norway, highlighting its growing presence in European research and forensic applications .

As a research chemical, MDPiHP is primarily utilized in neuropharmacological studies investigating dopamine transporter (DAT) inhibition, forensic analytical applications as a reference standard, and structure-activity relationship (SAR) studies within the cathinone class . At ForeverChems, we supply premium-grade MDPiHP Crystals to researchers and professionals worldwide, with a focus on fast, discreet shipping across Europe.

Product Specifications

Product Name: MDPiHP Crystals (3,4-Methylenedioxy-α-Pyrrolidinoisohexanophenone)

Synonyms: 3,4-Methylenedioxy PiHP, MDPiHP 

CAS Number: 24622-58-0 

Molecular Formula: C₁₇H₂₃NO₃ • HCl 

Molecular Weight: 325.83 g/mol (hydrochloride salt) 

Purity: ≥ 98% (verified by third-party HPLC testing) 

Form: Crystalline solid 

λmax: 236, 284, 322 nm 

Storage: -20°C for long-term stability 

Availability: In stock, ready for immediate dispatch

Chemical Properties and Mechanism of Action

MDPiHP belongs to the pyrovalerone-type synthetic cathinones, characterized by an N-pyrrolidinyl substitution that results in potent dopamine transporter (DAT) inhibition with high selectivity over the serotonin transporter (SERT) .

Core Mechanism: DAT Inhibition

The primary mechanism of action for MDPiHP is inhibition of the dopamine transporter (DAT). Research has demonstrated that MDPiHP is a significantly more potent hDAT inhibitor than cocaine, with IC₅₀ values showing it to be approximately 10-fold more potent than cocaine at inhibiting dopamine reuptake .

Quantitative Pharmacological Data

In vitro characterization has established the pharmacological profile of MDPiHP:

• DAT inhibition: MDPV and MDPiHP are among the most potent hDAT inhibitors in their class 

• SERT inhibition: Low affinity, resulting in a high DAT/SERT ratio indicative of high abuse potential 

• Compared to α-PiHP: The methylenedioxy substitution significantly enhances DAT potency compared to the parent compound 

In Vivo Findings

Repeated administration of MDPiHP in research models significantly increased preference scores in conditioned place preference (CPP) assays, even at the lowest dose tested, supporting a high abuse liability profile consistent with its potent DAT inhibition . The compound produces an inverted U-shaped dose-response curve in psychostimulant studies, likely due to the emergence of stereotypies at the highest doses tested .

Why Choose ForeverChems?

1. Uncompromising Quality

We source our MDPiHP Crystals from certified manufacturers with strict adherence to Good Manufacturing Practice (GMP) guidelines. Every batch undergoes independent HPLC and mass spectrometry testing to guarantee purity and potency, meeting the ≥98% purity standard expected for analytical reference materials .

2. Discreet and Secure Packaging

Your privacy is paramount. All orders are shipped in plain, unbranded packaging with no external markings indicating contents. Tamper-evident seals ensure security throughout transit.

3. Worldwide Shipping with European Focus

ForeverChems operates a robust global logistics network. We offer fast, reliable shipping to customers worldwide, with a particular emphasis on European markets:

• European Shipping: MDPiHP has been formally identified in European seizures and forensic cases . We have optimized shipping routes to ensure timely delivery to countries including Germany, France, the United Kingdom, Spain, Italy, the Netherlands, Sweden, Switzerland, Norway, and more.

• Fast Transit Times: Typical delivery to European destinations ranges from 3 to 7 business days.

• Tracking Provided: Every order comes with a tracking number for real-time shipment monitoring.

4. Competitive Pricing and Bulk Discounts

We offer tiered pricing for bulk orders, making ForeverChems the cost-effective choice for large-scale research projects. Contact our sales team for custom quotes.

5. Responsive Customer Support

Our knowledgeable team is available to answer queries regarding product specifications, shipping, and order status. We prioritize clear and prompt communication.

Safety and Regulatory Information

MDPiHP is a regulated substance in several European jurisdictions:

• Italy: Controlled 

• Lithuania: Controlled 

• Norway: Controlled 

• Sweden: Subject to health hazard regulation; recommended for inclusion on the narcotics ordinance 

As of 2023, the compound has not been placed on the 1961 or 1971 United Nations Conventions, though it has been reported to the UNODC . Due to its structural similarity to scheduled compounds like MDPV and α-PVP, which were placed in Schedule II of the 1971 Convention in 2015 and 2016, MDPiHP represents a compound of regulatory interest .

Important Considerations for Researchers:

• Controlled Status: MDPiHP is controlled in several European countries and may be subject to regulation in other jurisdictions. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

• Research Use Only: This product is intended for research, forensic, and analytical applications only. Not for human or veterinary use .

• Handling Precautions: Standard laboratory safety protocols should be followed when handling this compound.

Shipping Information: Worldwide Delivery

ForeverChems is committed to making our products accessible globally. We ship to all major regions, including:

• Europe: All EU member states, UK, Switzerland, Norway, and more.

• North America: USA, Canada, Mexico.

• Asia: Japan, South Korea, Singapore, China, India, and others.

• Australia & Oceania

• South America

• Middle East & Africa

Shipping Methods:

• Standard Air Mail (7-21 days, tracking available)

• Express Courier (3-7 days, fully tracked, signature required)

Customs and Duties: Customers are responsible for any customs duties or import taxes applicable in their country. We provide all necessary documentation to facilitate smooth customs clearance.

How to Order

1. Browse Our Catalog: Select MDPiHP Crystals and add to cart.

2. Checkout: Fill in your shipping details and choose your preferred payment method.

3. Payment: We accept cryptocurrencies and bank transfers for secure transactions.

4. Confirmation: Receive an order confirmation with tracking details upon dispatch.

Frequently Asked Questions

Q: What is MDPiHP used for?

A: MDPiHP is used as an analytical reference material for research and forensic applications, including transporter binding assays, neuropharmacological studies, and toxicological investigations .

Q: Is MDPiHP legal to purchase?

A: MDPiHP is controlled in Italy, Lithuania, and Norway, and is subject to regulation in other European countries . It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

Q: How should MDPiHP be stored?

A: Store at -20°C for long-term stability . The product is a crystalline solid with solubility in DMF, DMSO, ethanol, and PBS .

Q: What if my order is seized by customs?

A: While we take every precaution to ensure successful delivery, we cannot guarantee customs clearance in all countries. Please refer to our shipping policy for more details.