Introduction to 3-CMC.
buy 3CMC (3-Chloromethcathinone, also known as 3-chloroephedrone) is a synthetic cathinone belonging to the substituted cathinone class of compounds. It is the chlorinated analogue of 3-MMC, distinguished by the substitution of a chlorine atom at the 3-position of the phenyl ring. The compound has been identified as a new psychoactive substance (NPS) by the European Monitoring Centre for Drugs and Drug Addiction and has been circulating in the recreational drug market since approximately 2014 .
As a research chemical, 3-CMC is primarily utilized as a certified reference material for forensic and analytical applications. According to the EMCDDA’s latest drug report, 3-CMC accounted for approximately 34% of all synthetic cathinone seizures by EU Member States in 2021 . More recent data shows that in 2024, 3-CMC accounted for over 63% of all NPS seized in Europe, highlighting its growing significance in forensic casework . At ForeverChems, we supply premium-grade 3-CMC reference materials to researchers and professionals worldwide, with a focus on fast, discreet shipping across Europe.
Product Specifications
Product Name: 3-CMC (3-Chloromethcathinone)
Synonyms: 3-chloroephedrone, 3-chloromethcathinone
CAS Number: Not currently specified
Molecular Formula: C₁₀H₁₂ClNO
Molecular Weight: 197.66 g/mol
Purity: ≥ 98% (verified by third-party HPLC/GC-MS testing)
Form: Crystalline solid
Storage: -20°C for long-term stability
Availability: In stock, ready for immediate dispatch
Chemical Properties and Mechanism of Action
3-CMC belongs to the synthetic cathinone family, which are derivatives of the naturally occurring stimulant cathinone found in the khat plant. As a substituted cathinone, it acts as a monoamine transporter modulator, affecting dopamine, serotonin, and norepinephrine signaling in research models.
Key Pharmacological Data
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Mechanism: Non-selective monoamine releaser, acting at dopamine and serotonin transporters
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Structural Class: Substituted cathinone (chlorinated methcathinone analogue)
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Chiral Properties: Exists as a racemic mixture; enantioselective metabolism has been documented in research models
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Cytotoxicity: Research demonstrates that 3-CMC displays cytotoxicity against SH-SY5Y neuroblastoma cells, which emerges and intensifies after prolonged incubation
Analytical Applications
3-CMC is a recognized forensic reference material. It is included in GA/T 1925-2021, the Chinese public safety industry standard for the GC-MS and GC analysis of seven cathinone compounds in suspected drug samples, alongside 2-MMC, 3-MMC, 4-CMC, and other related substances . This inclusion underscores its established role in forensic toxicology.
Why Choose ForeverChems?
1. Uncompromising Quality
We source our 3-CMC reference materials from certified manufacturers with strict adherence to Good Manufacturing Practice (GMP) guidelines. Every batch undergoes independent HPLC and GC-MS testing to guarantee purity and potency, meeting the ≥98% purity threshold expected for analytical reference standards. Validation of methods for 3-CMC analysis has been established in biological matrices using GC-MS, as documented in recent research .
2. Discreet and Secure Packaging
Your privacy is paramount. All orders are shipped in plain, unbranded packaging with no external markings indicating contents. Tamper-evident seals ensure security throughout transit.
3. Worldwide Shipping with European Focus
ForeverChems operates a robust global logistics network. We offer fast, reliable shipping to customers worldwide, with a particular emphasis on European markets:
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European Shipping: 3-CMC is the most commonly seized synthetic cathinone in Europe, with prevalence in 25 EU Member States as well as Norway and Türkiye . We have optimized shipping routes to ensure timely delivery to all EU member states, the UK, Switzerland, and more.
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Fast Transit Times: Typical delivery to European destinations ranges from 3 to 7 business days.
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Tracking Provided: Every order comes with a tracking number for real-time shipment monitoring.
4. Competitive Pricing and Bulk Discounts
We offer tiered pricing for bulk orders, making ForeverChems the cost-effective choice for large-scale research projects. Contact our sales team for custom quotes.
5. Responsive Customer Support
Our knowledgeable team is available to answer queries regarding product specifications, shipping, and order status. We prioritize clear and prompt communication.
Safety and Regulatory Information
3-CMC is subject to regulatory control in multiple jurisdictions. As a chlorinated cathinone analogue, it has been associated with documented cases of acute poisoning . Research has demonstrated that 3-CMC can cause significant toxicity in target organs including the brain, liver, lungs, and kidneys in animal models .
Important Considerations for Researchers:
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Controlled Status: 3-CMC is regulated under narcotics or NPS legislation in numerous European countries and may be subject to control in other jurisdictions. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.
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Research Use Only: This product is intended for research, forensic, and analytical applications only, including GC-MS and LC-MS testing methods in forensic toxicology and clinical analysis . Not for human or veterinary use.
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Handling Precautions: Standard laboratory safety protocols should be followed when handling this compound. Studies have shown that 3-CMC exhibits low stability in biological samples, and the metabolite dihydro-3-CMC has been identified as a potential intake biomarker .
Shipping Information: Worldwide Delivery
ForeverChems is committed to making our products accessible globally. We ship to all major regions, including:
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Europe: All EU member states, UK, Switzerland, Norway, and more.
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North America: USA, Canada, Mexico.
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Asia: Japan, South Korea, Singapore, China, India, and others.
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Australia & Oceania
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South America
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Middle East & Africa
Shipping Methods:
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Standard Air Mail (7-21 days, tracking available)
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Express Courier (3-7 days, fully tracked, signature required)
Customs and Duties: Customers are responsible for any customs duties or import taxes applicable in their country. We provide all necessary documentation to facilitate smooth customs clearance, subject to local regulations.
How to Order
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Browse Our Catalog: Select 3-CMC and add to cart.
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Checkout: Fill in your shipping details and choose your preferred payment method.
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Payment: We accept cryptocurrencies and bank transfers for secure transactions.
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Confirmation: Receive an order confirmation with tracking details upon dispatch.
Frequently Asked Questions
Q: What is 3-CMC used for in research?
A: 3-CMC is used as an analytical reference material for forensic and toxicological applications, including GC-MS and LC-MS testing for the identification and quantification of synthetic cathinones in suspected drug samples and biological matrices .
Q: Is 3-CMC legal to purchase?
A: 3-CMC is regulated in many countries, particularly across Europe where it has been identified as the most commonly seized NPS. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.
Q: How should 3-CMC be stored?
A: Store at -20°C for long-term stability. Protect from light and moisture. Note that 3-CMC shows low stability in certain biological samples .
Q: What if my order is seized by customs?
A: While we take every precaution to ensure successful delivery, we cannot guarantee customs clearance in all countries, especially given the strict controls on 3-CMC. Please refer to our shipping policy for more details.
