introduction to PV-9 Crystals.
PV-9, also known as α-POP (alpha-pyrrolidinooctanophenone), is a synthetic cathinone belonging to the pyrovalerone class of compounds. It is a structural analogue of α-PVP, distinguished by an extended α-carbon side chain containing eight carbon atoms . The compound is also referred to as α-pyrrolidinooctanophenone and represents one of the newer generation pyrovalerone derivatives that emerged on the research chemical market around 2013 .
Within the research community, PV-9 is primarily utilized as an analytical reference standard for forensic and toxicological applications, including the identification and quantification of novel psychoactive substances in biological samples . At ForeverChems, we supply premium-grade PV-9 Crystals to researchers and professionals worldwide, with a focus on fast, discreet shipping across Europe.
Product Specifications
Product Name: PV-9 Crystals (α-POP; α-Pyrrolidinooctanophenone)
Synonyms: 1-Phenyl-2-(pyrrolidin-1-yl)octan-1-one, α-POP
Molecular Formula: C₁₈H₂₇NO
Molecular Weight: 273.41 g/mol (free base)
Purity: ≥ 98% (verified by third-party HPLC testing)
Form: Crystalline solid
Storage: Store at -20°C for long-term stability, or 4°C in a dry, sealed environment
Solubility: DMF: 12.5 mg/mL; DMSO: soluble; Ethanol: 25 mg/mL; PBS (pH 7.2): 2 mg/mL
Availability: In stock, ready for immediate dispatch
Chemical Properties and Mechanism of Action
PV-9 belongs to the α-pyrrolidinophenone class of synthetic cathinones, characterized by the replacement of the primary or N-methyl amine with a pyrrolidine ring and extension of the α-carbon side chain . This structural feature is responsible for the compound’s potent psychostimulatory properties.
Core Mechanism: DAT Inhibition
PV-9 acts primarily as a potent dopamine transporter (DAT) and norepinephrine transporter (NET) inhibitor, preventing the reuptake of these neurotransmitters from the synaptic cleft . Unlike some other cathinones that act as substrate releasers, pyrovalerone-type compounds function exclusively as reuptake inhibitors . The compound demonstrates negligible activity at the serotonin transporter (SERT), resulting in a high DAT/SERT selectivity ratio .
Structure-Activity Relationship
The length of the α-carbon side chain is a key determinant of pharmacological activity. Research indicates that extending the side chain beyond a certain point leads to decreased potency in vivo . While PV-9 produces marked psychostimulant effects, it does so with significantly lower potency than α-PVP, reflected in the higher doses recommended by users .
Interestingly, despite lower psychostimulant potency, PV-9 demonstrates markedly greater cytotoxicity than other α-pyrrolidinophenones, a finding that has significant implications for toxicological research . Cytotoxicity is attributed to mechanisms including oxidative stress-induced apoptosis and changes in plasma membrane fluidity .
Why Choose ForeverChems?
1. Uncompromising Quality
We source our PV-9 Crystals from certified manufacturers with strict adherence to Good Manufacturing Practice (GMP) guidelines. Every batch undergoes independent HPLC and mass spectrometry testing to guarantee purity and potency. Our reference standards meet the ≥98% purity threshold expected for reliable analytical applications .
2. Discreet and Secure Packaging
Your privacy is paramount. All orders are shipped in plain, unbranded packaging with no external markings indicating contents. Tamper-evident seals ensure security throughout transit.
3. Worldwide Shipping with European Focus
ForeverChems operates a robust global logistics network. We offer fast, reliable shipping to customers worldwide, with a particular emphasis on European markets:
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European Shipping: PV-9 has been detected across Europe and has been associated with forensic cases in multiple countries . We have optimized shipping routes to ensure timely delivery to countries including Germany, France, the United Kingdom, Spain, Italy, the Netherlands, Switzerland, Norway, and more.
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Fast Transit Times: Typical delivery to European destinations ranges from 3 to 7 business days.
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Tracking Provided: Every order comes with a tracking number for real-time shipment monitoring.
4. Competitive Pricing and Bulk Discounts
We offer tiered pricing for bulk orders, making ForeverChems the cost-effective choice for large-scale research projects. Contact our sales team for custom quotes.
5. Responsive Customer Support
Our knowledgeable team is available to answer queries regarding product specifications, shipping, and order status. We prioritize clear and prompt communication.
Safety and Regulatory Information
PV-9 is a regulated substance in many jurisdictions. It has been associated with numerous cases of acute poisoning and fatal overdoses across Europe and Japan . Fatal cases have documented postmortem blood concentrations of PV-9 as high as 0.743 µg/mL in polydrug intoxications . Common adverse effects include sympathomimetic toxidrome (tachycardia, hypertension, agitation), psychiatric disturbances (paranoid psychosis, hallucinations), seizures, and acid-base imbalance .
Important Considerations for Researchers:
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Controlled Status: PV-9 may be subject to regulation in various jurisdictions. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.
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Research Use Only: This product is intended for research, forensic, and analytical applications only. Not for human or veterinary use .
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Handling Precautions: Standard laboratory safety protocols should be followed when handling this compound. Given its potency and cytotoxicity profile, appropriate personal protective equipment is recommended.
Shipping Information: Worldwide Delivery
ForeverChems is committed to making our products accessible globally. We ship to all major regions, including:
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Europe: All EU member states, UK, Switzerland, Norway, and more.
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North America: USA, Canada, Mexico.
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Asia: Japan, South Korea, Singapore, China, India, and others.
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Australia & Oceania
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South America
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Middle East & Africa
Shipping Methods:
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Standard Air Mail (7-21 days, tracking available)
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Express Courier (3-7 days, fully tracked, signature required)
Customs and Duties: Customers are responsible for any customs duties or import taxes applicable in their country. We provide all necessary documentation to facilitate smooth customs clearance.
How to Order
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Browse Our Catalog: Select PV-9 Crystals and add to cart.
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Checkout: Fill in your shipping details and choose your preferred payment method.
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Payment: We accept cryptocurrencies and bank transfers for secure transactions.
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Confirmation: Receive an order confirmation with tracking details upon dispatch.
Frequently Asked Questions
Q: What is PV-9 used for in research?
A: PV-9 is used as an analytical reference standard for forensic and toxicological applications, including identification and quantification in biological samples, transporter binding assays, and neuropharmacological studies .
Q: Is PV-9 legal to purchase?
A: PV-9 is subject to regulation in many jurisdictions and may be controlled in various European countries. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order .
Q: How should PV-9 be stored?
A: Store at -20°C for long-term stability, or at 4°C in a dry, sealed environment. Ensure the product is protected from light and moisture .
Q: What if my order is seized by customs?
A: While we take every precaution to ensure successful delivery, we cannot guarantee customs clearance in all countries. Please refer to our shipping policy for more details.
