PV-9 Crystals: A Research Reference Overview

pv drug|PV-9, also known as α-pyrrolidinooctanophenone (α-POP), is a synthetic cathinone belonging to the pyrovalerone derivative class that has emerged in forensic toxicology literature as a novel psychoactive substance. At Foreverchems, we provide PV-9 crystals exclusively as qualified reference materials for laboratory research and analytical applications.

Chemical Profile

PV-9 is a higher homolog of α-PVP, distinguished by an extended aliphatic side chain. While α-PVP possesses a pentyl chain, PV-9 features an octyl chain, making it a C8 analog within the α-pyrrolidinophenone series . Its CAS number is 2749897-19-4, with a molecular formula of C₁₈H₂₇NO·HCl and a molecular weight of approximately 309.9 g/mol for the hydrochloride salt .

Pharmacologically, PV-9 functions as a transporter blocker rather than a substrate-releaser, binding to the dopamine transporter (DAT) and norepinephrine transporter (NET) to inhibit reuptake of these monoamines . The extended side chain increases lipophilicity, which may alter its volume of distribution and elimination half-life compared to shorter-chain homologs . Research indicates that extending the aliphatic side chain beyond the optimal length (typically C5 or C6) leads to decreased potency in vivo .

Research Context

PV-9 has been identified in forensic casework, including a fatal poisoning case documented in the Forensic Toxicology literature . Preclinical studies using in vivo microdialysis in mice have demonstrated that PV-9 stimulates locomotor activity and increases extracellular dopamine and serotonin levels in the striatum, though with lower potency than α-PVP when administered at equivalent doses .

Cytotoxicity research published in Neurotoxicity Research evaluated PV-9 alongside other pyrovalerone derivatives using human cell lines modeling neurons, hepatocytes, and airway epithelium. The study found that PV-9 and α-PVT were the most potent cytotoxic compounds tested, inducing pronounced mitochondrial dysfunction and significant cell membrane damage . These findings underscore the importance of analytical detection and characterization of this compound in research and forensic settings.

Quality Standards at Foreverchems

Every batch of PV-9 crystal undergoes comprehensive analytical verification. Our products are accompanied by certificates of analysis documenting purity levels, chemical identity, and relevant spectroscopic data. We maintain complete batch records for all reference materials, with HPLC and mass spectrometry data available for each lot.

Documentation and Compliance

Foreverchems provides certificates of analysis and technical documentation to support analytical and forensic research requirements. Our quality assurance framework includes standardized testing protocols and multi-stage verification processes.

Important Notice

PV-9 is a potent research chemical with no approved medical use . It poses significant risks of cardiovascular toxicity and neurotoxicity. Regulatory status varies by jurisdiction, and the compound may be subject to control under generic cathinone legislation or analog provisions in various countries. Researchers must verify their legal authority to handle such materials and comply with all applicable regulations in their location. Our products are supplied strictly for laboratory research and analytical reference purposes and are not intended for human consumption.